Current Research Studies

Research Studies and Clinical Trials

  • Search for "progressive supranuclear palsy", "corticobasal degeneration", or "multiple system atrophy".

  • The purpose of this study is to better understand why individuals with Progressive Supranuclear Palsy (PSP) fall. Understanding the mechanism of gait and balance dysfunction in individuals with PSP may provide us with important early diagnostic tools, allowing for earlier identification of mobility problems and to better evaluate medical therapies aimed at improving motor disability.

  • The hypothesis is that pyridostigmine will improve the safety factor of ganglionic neural transmission, while Droxidopa will replete the postganglionic neuron of norepinephrine (NE). This combination should result in enhanced orthostatic release of NE. The investigators have already demonstrated that pyridostigmine does not raise supine blood pressure.

  • The purpose of this study is to identify structural and functional changes in the brain using non-invasive neuroimaging techniques to develop sensitive and specific markers for each of these diseases, and then to track how these markers change as each disease progresses to a 2 year time point.

  • Conducted mainly at Vanderbilt University's Autonomic Dysfunction Center.

  • Noninvasive Cortical Stimulation (rTMS) for Motor and Non-Motor Features of Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD), sponsored by the UCLA School of Medicine.

  • The goal of this study is to identify the best methods of analysis for tracking PSP and CBD over time. The results from this study may be used in the future to calculate power for clinical drug trials, as this study aims to identify the most reliable outcome measures.

  • This study will use MRIs to analyze imaging biomarkers in order to distinguish patients with PSP and MSA from patients with Parkinson’s disease and Essential Tremors.