Based on this road map and goals, our key areas of interest are:

Pathway Grants:

– Autophagy/proteostasisSystem neuroscience (e.g., synaptic dysfunction or loss)
– Biological roles of GWAS hits
– Environmental causes and geographical clusters
– Nuclear architecture, epigenetics and transcription regulation
– Innate and adaptive immunity in tauopathies
– Mendelian families
– Validation of existing animal and human-derived preclinical models
– Sleep physiology
– Tau strains

Pipeline Grants:
– Validation of novel drug targets
– Cell replacement therapy/regenerative approaches
– Biomarker validation (diagnostic, disease progression, comorbidities)
– Prodromal and early-stage diagnostic markers
– Diagnostic platform validation (e.g., RT-QuIC)
– Proof-of-concept clinical trials
– Rehabilitation strategies for motor and nonmotor deficits
– RNA-based neuroprotection
– Symptomatic clinical drug trials
– Symptomatic clinical non-pharmacological trials

For further information contact Dr. Jennifer Brummet at brummet@curepsp.org 

Applications for the 2026 New Investigator Award grant program are now open. View application guidelines here. Apply on ProposalCentral by October 15, 2026, by 5pm US Eastern Time.

Through the CurePSP New Investigator Award grant program, CurePSP provides seed funding to early career investigators who have innovative ideas that need proof of concept or pilot studies in order to qualify for larger funding sources. CurePSP provides grants to scientists of up to $100,000, for one- or two-year studies. Investigators can be located in the U.S. or internationally. Proposals are carefully evaluated by our Scientific Advisory Board (SAB) and invited reviewers, in collaboration with our CEO and the Board of Directors.

CurePSP will fund studies focusing on PSP and CBD, two rare tauopathies. This grant program supports projects studying the fundamental neurobiology of PSP or CBD, and, translational projects focusing on new therapeutics and biomarkers for PSP and CBD. A more complete understanding of the underlying basic science and biochemical or molecular mechanisms of PSP and CBD will improve understanding of the diseases and provide foundational knowledge for future treatments. Examples of these types of projects include (but are not limited to) tau biology and pathobiology, epigenetics and epigenomics, synaptic dysfunction/loss, neuroinflammation, cellular vulnerability, lysosomal biology, glial biology, new preclinical models (i.e. organoids), or approaches that elucidate other underlying molecular or cellular mechanisms of PSP or CBD. Translational projects will accelerate the development of therapeutics that can prevent, treat, or cure PSP or CBD by accelerating the translation of basic science discoveries into disease modifying treatments. Examples of translational grant topics include (but are not limited to) symptomatic drug trials, the development of diagnostic biomarkers or other biomarkers with clear context of use, or rehabilitation strategies for motor and nonmotor deficits.

These studies offer donors the opportunity to name and be involved with hand-selected and intensively administered research that provides the greatest return on investment for the donor dollar.

Please note: The Pathway and Pipeline program was renamed to CurePSP New Investigator Program. The program's focus and eligibility remain the same.

Please visit our currently funded research grants page to learn more about currently funded research. 

Please visit our completed research grants to learn more about completed research studies.

CurePSP supports large research projects conducted by leading senior investigators at major institutions. These studies may have a longer time horizon and broader scope than our Venture Grants, and may involve joint funding from other sources. These studies have the potential of making major strides in the quest to find treatment and cure for neurodegeneration and as such provide significant opportunities for donor recognition and involvement.

Please visit our Enterprise Grants page to learn more about this research. 

CurePSP Student Fellowships support students and trainees conducting summer research projects focused on PSP, CBD or MSA. The goal of these programs is to encourage trainees to pursue research in this field in an effort to make PSP, CBD and MSA a long-term area of research interest and to further our understanding of these diseases

Please visit our Student Fellowship page to learn more. 

The Alzheimer’s Association, The Michael J. Fox Foundation for Parkinson’s Research (MJFF) and CurePSP are partnering together on this unique funding program to advance an understanding of the role sleep plays in neurodegeneration, including Alzheimer’s disease, Parkinson’s disease, Lewy body diseases and Progressive Supranuclear Palsy. This funding call will focus on projects aimed to advance our understanding of the impact that sleep and related biology (including circadian rhythms) have as both a contributor to and a consequence of neurodegeneration. Projects funded through this program will aim to tackle the proposed question with a multidisciplinary team and projects that engage in team science approaches will be given preference. 

Please visit this page to learn more.

Applications for the Biomarker Accelerator Program are now open. Letters of Intent are due by December 15, 2025. Application instructions and eligibility guidelines are available here.