Research

CurePSP recognizes that the fight against PSP, CBD, and other disorders can now take a new direction, capitalizing on a number of recent discoveries, exciting ongoing work, and new hypotheses. Please watch this video to learn more about PSP and CBD research. On November 12, 2015, a group of eminent CurePSP grantees, moderated by Pulitzer Prize-winning author Jonathan Weiner, discussed the latest development in neurodegeneration research.

The Theory of Everything - A group of eminent investigators, moderated by Pulitzer Prize-winning author Jonathan Weiner, discussed the latest development in neurodegeneration research.

The Theory of Everything - A group of eminent investigators, moderated by Pulitzer Prize-winning author Jonathan Weiner, discussed the latest development in neurodegeneration research.

Research Road Map

To this end, CurePSP created the CurePSP Research Road Map to help guide the organization’s future scientific endeavors toward treatment and a cure. The Road Map will focus on three ideas in which PSP and CBD may occur—genes, prions, and proteins. It will also focus on obtaining two tools used to explore those ideas, new models and new genetic markers. When combined, the Road Map hopes to accomplish four goals:

– Identify new drug targets
– Screen potential drugs
– Develop tests using animal models
– Implement both small and large scale testing in human patients

For further information contact Lawrence I. Golbe, MD, Director of Scientific Affairs, at golbe@curepsp.org.

Based on this road map and goals, we composed a document with our research focus for 2019-20. The key areas of interest are:

– autophagy/proteostasis
– cell replacement therapy/regenerative approaches
– diagnostic markers in very early stage disease
– environmental causes and geographical clusters
– epigenetics
– GSK3ß and other kinases/phosphorylases
– inflammation
– Mendelian families
– nucleochromatin
– rehabilitation strategies for motor and nonmotor deficits
– RNA-based neuroprotection
– single cell sequencing
– sleep physiology
– symptomatic drug trials
– synaptic dysfunction/loss
– tau strains

For further information contact theLawrence I. Golbe, MD, Director of Scientific Affairs, at golbe@curepsp.org.

Research Grants

The next Venture Grant deadline is September 27, 2019.

CurePSP provides “seed funding” to investigators who have innovative ideas that need “proof of concept” in order to qualify for larger funding sources.

CurePSP will fund studies on PSP and CBD with a particular interest in (i) molecular and cellular (pathological) mechanisms that may operate also in related diseases and (ii) translational clinical research involving PSP and CBD patients.

We provide grants to scientists of up to $100,000 for one- or two-year studies. These are carefully evaluated by our distinguished global Scientific Advisory Board (SAB) in collaboration with our Vice President-Scientific Affairs and the Board of Directors Research Committee. Because of that, these studies offer donors the opportunity to name and be involved with hand-selected and intensively administered research that provides the greatest return on investment for the donor dollar.

Please visit our Venture Grants page to learn more about them.

Please visit our Currently Funded Venture Grants page to learn more about currently funded research. 

Please visit our Venture Grants Archive to learn more about completed research studies.

CurePSP supports large research projects conducted by leading senior investigators at major institutions. These studies may have a longer time horizon and broader scope than our Venture Grants, and may involve joint funding from other sources. These studies have the potential of making major strides in the quest to find treatment and cure for neurodegeneration and as such provide significant opportunities for donor recognition and involvement.

Please visit our Enterprise Grants page to learn more about this research. 

The CurePSP Urso Student Fellowship supports students conducting summer research projects focused on PSP, CBD, and related diseases. This program is supported by the Paul and Ruth Urso Memorial Research Fund. The goal of this fellowship program is to encourage students at all post-secondary levels to pursue research in this field in the hope of making PSP or CBD a long-term area of research interest. Projects may be in basic, translational, clinical, or epidemiological aspects of PSP and CBD.

Please visit our Student Fellowship page to learn more. 

PSP Research Roundtable

The PSP Research Roundtable is a pre-competitive collaboration involving patient advocacy organizations, academia, and selected industry leaders. Its mission is to represent the field in addressing bottlenecks and accelerating the development of new treatments for PSP and other primary tauopathies.

PSP Genetics Consortium

genetics-cons-croppedThe PSP Genetics Consortium is a group of neurologists, geneticists, and other neuroscientists from the United States, United Kingdom and Germany, studying the underlying genetics of PSP. The goal of this multi-national approach is to search the entire human genome for genes linked to PSP and related disorders. The PSP Genetics Consortium is a collaboration between CurePSP and the Tau Consortium. 

Brain Donation

The brain bank at the Mayo Clinic in Jacksonville, Florida, supported by CurePSP, provides an invaluable resource to investigators by providing tissue samples for their research. It also provides a postmortem confirmation of diagnosis to families of the deceased. CurePSP reimburses families for the costs of brain donation.

Clinical Trials

There are a number of clinical trials being undertaken at any given time that may present opportunity for patient participation. CurePSP will endeavor to keep this list as up to date as possible.

The FTD Disorders Registry

The Registry is an online database to collect information from those affected by all types of prime of life brain diseases, such as PSP, CBD, and related. Persons diagnosed, (current/former) caregivers, family, and friends can join. As a member of the Registry, you can help us advance the science and move faster toward finding treatments and cures. Join the registry here. 

Research Symposiums

CurePSP and the PSP Association jointly hosted the First International Research Symposium on PSP & CBD at the Royal College of Physicians in London, UK, on October 25 and 26, 2018. Please click here to read the full program. Around 230  scientists from around the globe came to London to discuss the latest research in PSP and CBD. You can read a scientific summary on Alzforum here.

CurePSP held its annual International Research Symposium in San Francisco on October 26/27, 2017.  This symposium highlighted research by CurePSP grantees and key opinion leaders from academia and pharma/biotech interested in clinical and basic studies of PSP, CBD, and related tauopathies. See the full program here.

CurePSP held its annual International Research Symposium in New York on October 27/28, 2016.  This symposium highlighted research by CurePSP grantees and key opinion leaders from academia and pharma/biotech interested in clinical and basic studies of PSP, CBD, and related tauopathies. See the full program here.

CurePSP held its annual International Research Symposium at the Scripps Institute in La Jolla, CA on November 5-7, 2015.  This symposium highlighted research by CurePSP grantees and key opinion leaders from academia and pharma/biotech interested in clinical and basic studies of PSP, CBD, and related tauopathies. See the full program here.