Prime of Life Brain Diseases

Neurodegeneration is not just a disease that strikes the elderly. There is a spectrum of brain diseases that often onset in the 50’s and 60’s when people may have family responsibilities, careers, and active lives. Half of all neurodegeneration under age 65 involves these diseases (NIH).

What is a Tauopathy?

PSP, CBD, and several other diseases, including Alzheimer’s, are considered tauopathies. This is because the neurodegenerative symptoms are due to the abnormal misfolding and clumping of the tau protein within neurons, which causes progressive cell death. 

Frequently Asked Questions

We welcome your questions so that we can share answers with others. If one of your questions is not answered here, please submit through and we will attempt to provide an answer and may include it in this section for the benefit of others.

The CurePSP Guidebook

We are proud to bring you the 2018 CurePSP Guidebook. This signature publication features 150 pages of the latest information on PSP, CBD, and MSA and is the perfect reference for patients, family, care partners, and health professionals. The Guidebook is available for a suggested donation of $20 at this page.

Alternatively, call our Donations Processing Officer, Alisa Hansen, at 443-578-5670 or email

Patient Resources

A key part of CurePSP’s mission of care, consciousness, and cure is to provide relevant, up-to-date information on prime of life brain diseases. These resources are for patients, families, and friends seeking to educate themselves, and others, about these diseases; the causes, the symptoms, the disease trajectory, treatments, management, etc. This information is sourced from credible peer-reviewed scientific sources only and is updated as breakthroughs in our understanding of these diseases occur.

Resources for Healthcare Professionals

CurePSP strives to provide allied healthcare professionals with up-to-date information on these prime of life diseases to assist them in diagnosing, treating and managing these diseases. We encourage you to download, print, and share these resources among your allied medical network.


CurePSP has a comprehensive plan and program for pursuing research that may ultimately find treatment and cure for PSP and other prime of life neurodegenerative diseases. Research is now showing that all neurodegeneration is likely linked by common pathology, so that our research may eventually unlock the secrets of more-common illnesses like Alzheimer’s and Parkinson’s.

CurePSP has supported more than 190 research studies since its founding in 1990 primarily in progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA). This effort continues today with several important ongoing projects.