About Our Research
Research Road Map
CurePSP recognizes that the fight against PSP and other disorders can now take a new direction, capitalizing on a number of recent discoveries, exciting ongoing work and new hypotheses.
To this end, CurePSP created the CurePSP Research Road Map to help guide the organization’s future scientific endeavors toward treatment and a cure. The Road Map will focus on three ideas in which PSP and other diseases may occur—genes, prions, and proteins. It will also focus on obtaining two tools used to explore those ideas—new models and new genetic markers. When combined, the Road Map hopes to accomplish five goals:
– Identify new drug targets
– Screen potential drugs
– Develop tests using animal models
– Implement both small and large scale testing in human patients
Based on this road map and goals, we composed a document with our research focus for 2016-17. The key areas of interest are:
– Etiology/Pathogenesis of PSP/CBD and related disorders
– Development of validated models of PSP and related disorders
– Identification and validation of disease-specific biomarkers
– Clinical studies focused on obtaining ‘proof of concept’ for novel therapeutics
– Patients with PSP and related disorders
– Investigating the potential of cell therapy and regenerative medicine
– iPS cells and gene editing
For further information contact Dr. Alex Klein at email@example.com.
The PSP Genetics Consortium is a group of neurologists, geneticists, and other neuroscientists from the United States, United Kingdom and Germany, studying the underlying genetics of PSP. The goal of this multi-national approach is to search the entire human genome for genes linked to PSP and related disorders. The PSP Genetics Consortium is a collaboration between CurePSP and the Tau Consortium.
The brain bank at the Mayo Clinic in Jacksonville, Florida, supported by CurePSP, provides an invaluable resource to investigators by providing tissue samples for their research. It also provides a postmortem confirmation of diagnosis to families of the deceased. CurePSP reimburses families for the costs of brain donation.
Patient Engagement Program
Clinical trials are required to bring drugs to market. They are often undertaken by pharmaceutical companies and academic institutions when treatments have shown promise in animal models. They are stringently regulated by the U.S. Food and Drug Administration and are usually expensive, lengthy and fraught with challenges. CurePSP formed the Patient Engagement Program to help expedite clinical trials by securing patients (“cohorts”), educating physicians about clinical trials and easing the patient journey through the trials.
There are a number of clinical trials being undertaken at any given time that may present opportunity for patient participation. CurePSP will endeavor to keep this list as up to date as possible.
CurePSP Venture Grants
CurePSP provides “seed funding” to investigators who have innovative ideas that need “proof of concept” in order to qualify for larger funding sources. We provide grants to scientists of up to $100,000 for one- or two-year studies. These are carefully evaluated by our distinguished global Scientific Advisory Board (SAB) in collaboration with our Vice President-Scientific Affairs and the Board of Directors Research Committee. Because of that, these studies offer donors the opportunity to name and be involved with hand-selected and intensively administered research that provides the greatest return on investment for the donor dollar.
CurePSP Enterprise Grants
CurePSP supports large research projects conducted by leading senior investigators at major institutions. These studies may have a longer time horizon and broader scope than our Venture Grants, and may involve joint funding from other sources. These studies have the potential of making major strides in the quest to find treatment and cure for neurodegeneration and as such provide significant opportunities for donor recognition and involvement.
Urso Summer Student Fellowships
The Urso Summer Student Program in PSP Research recognizes the generous support of Paul and Ruth Urso.
The Urso Summer Student Program in PSP Research will support students conducting summer research projects focused on progressive supranuclear palsy. This program seeks to encourage students at all post-secondary levels to pursue research in this field in the hope of making PSP a long-term area of research interest. Projects may be in basic, translational, clinical or epidemiological aspects of PSP.