2015 International Research Symposium

CurePSP conducts an annual International Research Symposium to facilitate dissemination of advances in the fields of PSP, CBD, MSA, and related brain diseases. This symposium highlights research by CurePSP grantees and is open to all researchers interested in clinical and basic studies of PSP, CBD, and related tauopathies. The Research Symposium also assists the Scientific Advisory Board in identifying work of exceptional promise, which may then be considered for additional funding.



Thursday, November 5

Reception, 7:00 pm - 8:30 pm, Grande Colonial, Sun Room, 910 Prospect Street, La Jolla, CA

Friday, November 6

Shuttles from Grande Colonial hotel to Scripps Seaside Forum leave promptly at 7:00 am and 7:30 am.

Registration and Breakfast: 7:00 am - 8:00 am, Scripps Seaside Forum, 8610 Kennel Way, La Jolla, CA

Symposium: 8:00 am - 5:20 pm

Cocktail reception: 5:20 pm - 7:00 pm

Shuttle from Scripps Seaside Forum to Grande Colonial hotel leaves promptly at 7:00 pm.

Saturday, November 7

Working Brunch: 9:30 am - 12:30 pm, La Valencia Hotel, 1132 Prospect Street, La Jolla, CA

Symposium Agenda


7:00 am – 8:00 am  

Welcome and Introductions

8:00 am – 8:15 am   

  • William R. McFarland, Chair, Board of Directors, CurePSP
  • Lawrence I. Golbe, MD, Robert Wood Johnson Medical School
  • Jeffrey S. Friedman, MD, PhD, Friedman Bioventure


8:15 am - 9:00 am

Marc Diamond, MD, University of Texas Southwestern Medical Center, "Tau seeding activity and strain composition in tauopathy syndromes."


9:00 am - 9:45 am

Kenneth S. Kosik, MD, University of California, Santa Barbara

Mid-Morning Break

9:45 am - 10:00 am

Brain Bank Update

10:00 am - 10:30 am   

Dennis W. Dickson, MD, Mayo Clinic 


10:30 am - 11:15 am   

Jeffery W. Kelly, PhD, The Scripps Research Institute, "Chemical and biological adaptation of proteostasis to ameliorate degenerative diseases."

Clinical Trials Overview

11:15 am - 12:00 pm   

Adam Boxer, MD, PhD, University of California, San Francisco

Lunch and Posters

12:00 pm - 1:30 pm   

Panel on Clinical Trials

1:30 pm - 2:45 pm   

  • Chair: Adam Boxer, MD, PhD, University of California, San Francisco
  • Joel B. Braunstein, MD, MBA, C2N Diagnostics
  • Trish Caruana, MSW, CurePSP and Patient Engagement Program (PEP)
  • Günter U. Höglinger, MD, German Center for Neurodegenerative Diseases/Technical University of Munich
  • Roger Lane, MD, MPH, Isis Pharmaceuticals
  • Irfan Qureshi, MD, Bristol-Myers Squibb
  • Darryle Schoepp, PhD, Merck
  • Christoph Wiessner, PhD, Asceneuron S.A.

Research Grant Presentation

2:45 pm - 3:10 pm   

Grantee: Christoph Wiessner, PhD, Asceneuron S.A., "O-GlcNAcylation of tau: From basic mechanisms to new therapeutics for PSP."


3:10 pm - 3:25 pm   

Research Grant Presentation

3:25 pm - 3:50pm   

Grantee: Natura Myeku, PhD, Columbia University, Taub Institute for Alzheimer's Disease Research, "26S proteasome dysfunction and cognitive impairment caused by aggregated tau accumulation can be attenuated by PKA-mediated phosphorylation of proteasomes."

Panel on Genetics and Epigenetics

3:50 pm - 5:05 pm   

  • Chair: Jeffrey S. Friedman, MD, PhD, Friedman Bioventure
  • Gerard Schellenberg, PhD, Perelman School of Medicine, University of Pennsylvania
  • Giovanni Coppola, MD, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles
  • Günter U. Höglinger, MD, German Center for Neurodegenerative Diseases/Technical University of Munich

Summative Discussion

5:05 pm - 5:20 pm   

Cocktail Reception

5:20 pm - 7:00 pm